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Descriptions taken from the
University of Washington Research Center

Inactivation of Neurotransmitters

The action of neurotransmitters can be
stopped by four different mechanisms
1. Diffusion: the neurotransmitter drifts away, out of the synaptic cleft where it can no longer act on a receptor. Diffusion
2. Enzymatic degradation (deactivation): a specific enzyme changes the structure of the neurotransmitter so it is not recognized by the receptor. For example, acetylcholinesterase is the enzyme that breaks acetylcholine into choline and acetate. Enzymatic degradation
3. Glial cells: astrocytes remove neurotransmitters from the synaptic cleft.
Astrocyte
Image courtesy of Biodidac
4. Reuptake: the whole neurotransmitter molecule is taken back into the axon terminal that released it. This is a common way the action of norepinephrine, dopamine and serotonin is stopped...these neurotransmitters are removed from the synaptic cleft so they cannot bind to receptors. Reuptake

Source: "Neurotransmitters for Kids"; Eric H. Chudler, Ph.D.;
University of Washington; Seattle, Washington 98195-6540
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